Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

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This Usera€™s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The Usera€™s Guide was created by researchers affiliated with AHRQa€™s Effective Health Care Program, particularly those who participated in AHRQa€™s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)It is therefore crucial for researchers and users of PRO data to understand the scoring system being used for an instrument ... These may range from individuals who can self-report, to individuals requiring the assistance of a proxy or medical ... Some PRO questionnaires are entirely in the public domain and are free for use.


Title:Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide
Author: Agency for Health Care Research and Quality (U.S.)
Publisher:Government Printing Office - 2013-02-21
ISBN-13:

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